Isobaric tag for relative and absolute quantitation

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Isobaric tag for relative and absolute quantitation (iTRAQ)
Chemical labeling reagents used for relative or absolute quantitation in proteomics, based on covalent labeling of the N-terminus and side-chain amines of peptides from protein digestions with tags of varying mass.
Related Term(s):

P. L. Ross, Y. N. Huang, J. N. Marchese, B. Williamson, K. Parker, S. Hattan, N. Khainovski, S. Pillai, S. Dey, S. Daniels, S. Purkayastha, P. Juhasz, S. Martin, M. Bartlet-Jones, F. He, A. Jacobson, D. J. Pappin. Mol. Cell Proteomics 3, 1154 (2004).

L. R. Zieske. J. Exp. Bot. 57, 1501 (2006). ( )

From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.

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