Isotope-coded affinity tag

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Isotope-coded affinity tag (ICAT)
Chemical labeling reagents used for relative quantitation in proteomics, consisting of a reactive group capable of labeling a defined amino acid side-chain, an isotopically coded linker, and a tag for the affinity isolation of labeled proteins and peptides.
Related Term(s):

S. P. Gygi, B. Rist, S. A. Gerber, F. Turecek, M. H. Gelb, R. Aebersold. Nat. Biotech. 17, 994 (1999). ( )

From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.

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