Protein footprinting

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DRAFT DEFINITION
Protein footprinting
Method for protein structure determination using oxidative modification of amino acid side chains in the presence of H218O with subsequent analysis by mass spectrometry.
Related Term(s): Hydrogen/deuterium exchange, Peptide mass fingerprinting, Stable isotope labeling
Reference(s):
S. D. Malekni, M Brenowitz, and M. R. Chance, Millisecond Radiolytic Modification of Peptides by Synchrotron X-rays Identified by Mass Spectrometry, Anal. Chem. 1999 71, 3965-3973, http://dx.doi.org/10.1021/ac990500e
This is an unofficial draft definition presented for information and comment.

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