Selected ion monitoring
| IUPAC RECOMMENDATIONS 2013
K. K. Murray, R. K. Boyd, M. N. Eberlin, G. J. Langley, L. Li and Y. Naito, Pure Appl. Chem., 2013, 85, 1515-1609, 10.1351/PAC-REC-06-04-06.
|Selected ion monitoring , SIM'|
|Deprecated: multiple ion detection, mass fragmentography, selected ion recording.|
|Related Term(s): selected reaction monitoring|
IUPAC. Analytical Division. Compendium of Analytical Nomenclature (the “Orange Book”). Definitive Rules, 1979. Compiled by J. Inczédy, T. Lengyel, A. M. Ure. Blackwell Scientific Publications, Oxford (1997). On-line corrected version: http://www.iupac.org /publications/analytical compendium (2000).
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the “Gold Book”). Compiled by A. D. McNaught and A.Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins.
J. T. Watson. Introduction to Mass Spectrometry, Lippincott-Raven, Philadelphia (1997).
|Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.|
| ORANGE BOOK DEFINITION
IUPAC. Analytical Division. Compendium of Analytical Nomenclature (the “Orange Book”). Definitive Rules, 1979.
|Selected ion monitoring|
This term is used to describe the operation of the mass spectrometer in which the intensities of several specific ion beams are recorded rather than the entire mass spectrum. An alternative recommended term is multiple ion (peak) monitoring. The use of the terms multiple ion detection and 'mass fragmentography' is not recommended.
|IUPAC Orange Book Chapter 12|
|Index of Orange Book Terms|
| GOLD BOOK DEFINITION
IUPAC. Compendium of Chemical Terminology, 2nd ed. (the “Gold Book”). Compiled by A. D. McNaught and A.Wilkinson. Blackwell Scientific Publications, Oxford (1997).
|Selected ion monitoring|
This term is used to describe the operation of the mass spectrometer in which the intensities of several specific ion beams are recorded rather than the entire mass spectrum. An alternative recommended term is multiple ion (peak) monitoring. The use of the terms multiple ion detection and mass fragmentography are not recommended, because in the case of the former, it is the monitoring of several peaks which should be emphasized rather than the detection of different ions, and in the case of the latter it is often not fragments that are being monitored but peaks from molecular ions.
Source: PAC, 1991, 63, 1541 (Recommendations for nomenclature and symbolism for mass spectroscopy (including an appendix of terms used in vacuum technology). (Recommendations 1991)) on page 1551
|IUPAC Gold Book|
|Index of Gold Book Terms|
Multiple reaction monitoring is not deprecated
Please note that the term multiple reaction monitoring is not deprecated in the IUPAC "Standard definitions of terms relating to mass spectrometry" Pure Appl. Chem., 2013, 85, 1515. There is no small amount of confusion regarding this fact due in part to the seven years that elapsed between the posting of the unreviewed 2006 draft of the document (still linked as "provisional recommendations" on the IUPAC website) and the publication of the peer reviewed document in 2013. Comments from reviewers during the peer review process led to a revision of the definition to what is now indicated on the multiple reaction monitoring page of this wiki. In several publications between 2006 and 2012, the draft definition was cited (e.g. http://dx.doi.org/10.1038/msb.2008.61, http://dx.doi.org/10.1002/pmic.200800577, http://dx.doi.org/10.1039/c0mb00159g, http://dx.doi.org/10.1002/pmic.201200042), inadvertently leading to further confusion. Again, please note that the IUPAC recommendation for multiple reaction monitoring is the one indicated in http://dx.doi.org/10.1351/PAC-REC-06-04-06.
Summary of reaction monitoring definitions
Term Acronym Definition Diagram Reference Selected ion monitoring SIM Operation of a mass spectrometer in which the abundances of ions of one or more specific m/z values are recorded rather than the entire mass spectrum. • Gold Book Selected reaction monitoring SRM Data acquired from one or more specific product ions corresponding to m/z selected precursor ions recorded via two or more stages of mass spectrometry. de Hoffmann. J. Mass Spectrom. 31, 129 (1996). Consecutive reaction monitoring CRM Multiple-stage mass spectrometry experiment with three or more stages of m/z separation in which products of sequential fragmentation or bimolecular reactions are selected for detection. Tomer, Guenat, Deterding. Anal. Chem. 60, 2232 (1988). Multiple reaction monitoring MRM Application of selected reaction monitoring to multiple product ions from one or more precursor ions.
- Note: This term should not be confused with consecutive reaction monitoring, which involves the serial application of three or more stages of selected reaction monitoring.
Roepstorff, Fohlman. Biomed. Mass Spectrom. 11, 601 (1984).
|This term has a corresponding Wikipedia article: Selected ion monitoring|