Stable isotope labeling of amino acids in cell culture

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IUPAC RECOMMENDATIONS 2013
Stable isotope labeling of amino acids in cell culture (SILAC)
Proteomics technique that detects differences in protein abundance between cultured cell samples using stable isotopic labeling achieved with labeled amino acids in one cell culture and unlabeled ones in a separate culture.
Related Term(s):
Reference(s):

H. Jiang, A. M. English. J. Proteome Res. 1, 345 (2002). (http://dx.doi.org/10.1021/pr025523f )

S. E. Ong, B. Blagoev, I. Kratchmarova, D. B. Kristensen, H. Steen, A. Pandey, M. Mann. Mol. Cell Proteomics 1, 376 (2002).

H. Zhu, S. Pan, S. Gu, E. M. Bradbury, X. Chen. Rapid Commun. Mass Spectrom. 16, 2115 (2002). (http://dx.doi.org/10.1002/rcm.831 )

From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.

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