Surface-enhanced laser desorption/ionization

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Surface-enhanced laser desorption/ionization
Variant of matrix-assisted laser desorption/ionization (MALDI) in which the matrix is replaced by a surface coating of a chromatographic stationary phase designed to selectively retain different subsets of proteins or peptides from a mixture depending on their physico-chemical properties or biochemical affinity characteristics.
Note: Originally this technique was named surface-enhanced affinity capture (SEAC) to distinguish it from surface-enhanced neat desorption (SEND) where the surface coating is designed to increase the efficiency of laser desorption.
Related Term(s):

T. W. Hutchens, T. T. Yip. Rapid Commun. Mass Spectrom. 7, 576 (1993). ( )

T. C. W. Poon. Exp. Rev. Proteomics 4, 51 (2007). ( )

From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.

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