Surrogate internal standard

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Surrogate internal standard
surrogate internal standard

internal standard

Compound added in accurately known amounts to a sample to be analyzed for a specified analyte. The surrogate internal standard is chemically similar to the analyte so that losses in the analytical procedure are the same for both and thus the analyte concentration can be determined relative to that of the standard.

Note 1: In quantitative mass spectrometry the preferred type is an isotope-labeled version of the analyte.
Note 2: The abbreviated term internal standard is often used.
Related Term(s): volumetric internal standard
From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.

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