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IUPAC reaction monitoring terms
Term Acronym Definition Diagram Reference Selected ion monitoring SIM Operation of a mass spectrometer in which the abundances of ions of one or more specific m/z values are recorded rather than the entire mass spectrum. . Gold Book Selected reaction monitoring SRM Data acquired from one or more specific product ions corresponding to m/z selected precursor ions recorded via two or more stages of mass spectrometry. de Hoffmann. J. Mass Spectrom. 31, 129 (1996). Consecutive reaction monitoring CRM Multiple-stage mass spectrometry experiment with three or more stages of m/z separation in which products of sequential fragmentation or bimolecular reactions are selected for detection. Tomer, Guenat, Deterding. Anal. Chem. 60, 2232 (1988). Multiple reaction monitoring MRM Application of selected reaction monitoring to multiple product ions from one or more precursor ions.
- Note: This term should not be confused with consecutive reaction monitoring, which involves the serial application of three or more stages of selected reaction monitoring.
Roepstorff, Fohlman. Biomed. Mass Spectrom. 11, 601 (1984).