Shotgun proteomics

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Shotgun proteomics
Protein identification using a combination of high-performance liquid chromatography and mass spectrometry in which the proteins in a mixture are digested, usually by a specific enzyme, and the resulting peptides are separated by liquid chromatography and identified by tandem mass spectrometry.
Related Term(s): bottom-up proteomics

M. L. Fournier, J. M. Gilmore, S. A. Martin-Brown, M. P. Washburn. Chem. Rev. 107, 3654 (2007). ( )

From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.

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