Difference between revisions of "Template:MRM deprecation"

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==Confusion regarding multiple reaction monitoring deprecation==
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==Multiple reaction monitoring is not deprecated==
Please note that the term [[multiple reaction monitoring]] is not deprecated in the IUPAC ''[http://www.iupac.org/projects/2003/2003-056-2-500.html Standard definitions of terms relating to mass spectrometry]''. There is some confusion regarding this fact due to the seven years that elapsed between the posting of the unreviewed 2006 draft of the document (still linked as "[http://www.iupac.org/home/publications/provisional-recommendations/published/published-container/standard-definitions-of-terms-relating-to-mass-spectrometry.html provisional recommendations]" on the IUPAC website) and the publication of the [http://dx.doi.org/10.1351/PAC-REC-06-04-06 peer reviewed document] in 2013. Comments from reviewers during the peer review process led to a revision of the definition indicated on the [[multiple reaction monitoring]] page of this wiki. In at least one publication between 2006 and 2012, the draft definition was cited (e.g. {{doi}}10.1038/msb.2008.61, {{doi}}10.1002/pmic.201200042, {{doi}}10.1039/c0mb00159g, {{doi}}10.1002/pmic.200800577, {{doi}}10.1002/pmic.201200042), inadvertently leading to further confusion. Again, please note that the IUPAC recommendation for [[multiple reaction monitoring]] is the one indicated in {{doi}}10.1351/PAC-REC-06-04-06.  
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Please note that the term [[multiple reaction monitoring]] '''is not deprecated''' in the IUPAC "[http://www.iupac.org/projects/2003/2003-056-2-500.html Standard definitions of terms relating to mass spectrometry]" ''Pure Appl. Chem.'', '''2013''', ''85'', 1515. There is no small amount of confusion regarding this fact due in part to the seven years that elapsed between the posting of the unreviewed 2006 draft of the document (still linked as "[http://www.iupac.org/home/publications/provisional-recommendations/published/published-container/standard-definitions-of-terms-relating-to-mass-spectrometry.html provisional recommendations]" on the IUPAC website) and the publication of the [http://dx.doi.org/10.1351/PAC-REC-06-04-06 peer reviewed document] in 2013. Comments from reviewers during the peer review process led to a revision of the definition to what is now indicated on the [[multiple reaction monitoring]] page of this wiki. In several publications between 2006 and 2012, the draft definition was cited (e.g.  
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{{doi}}10.1038/msb.2008.61,  
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{{doi}}10.1002/pmic.200800577,  
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{{doi}}10.1039/c0mb00159g,  
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{{doi}}10.1002/pmic.201200042),  
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inadvertently leading to further confusion. Again, please note that the IUPAC recommendation for [[multiple reaction monitoring]] is the one indicated in {{doi}}10.1351/PAC-REC-06-04-06.  
  
<includeonly>[[Category:Reactions]]</includeonly>
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===Summary of reaction monitoring definitions===
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:{| class="wikitable"  border="1" style="border-collapse:collapse;" style="border-spacing: 1px; border: 5px solid purple;"
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|-
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! Term
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!Acronym
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! Definition
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! Diagram
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! Reference
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|-
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|[[Selected ion monitoring]]
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|[[SIM]]
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|Operation of a [[mass spectrometer]] in which the abundances of [[ion]]s of one or more specific ''[[m/z]]'' values are recorded rather than the entire [[mass spectrum]].
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|&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<big><big>.</big></big>
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|[[Gold Book]]
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|-
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| [[Selected reaction monitoring]]
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|[[SRM]]
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| Data acquired from one or more specific product [[ion]]s corresponding to [[m/z]] selected [[precursor ion]]s recorded via two or more stages of [[mass spectrometry]].
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:''Note 1'': Selected reaction monitoring in [[multiple-stage mass spectrometry]] is known as [[consecutive reaction monitoring]].
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:''Note 2'': Selected reaction monitoring applied to multiple product ions from one or more [[precursor ion]]s is known as multiple reaction monitoring.
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|[[File:SRM.jpg|center|20 px]]
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|de Hoffmann. J. Mass Spectrom. 31, 129 (1996).
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|-
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| [[Consecutive reaction monitoring]]
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|[[CRM]]
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| [[Multiple-stage mass spectrometry]] experiment with three or more stages of [[m/z]] separation in which products of sequential fragmentation or bimolecular reactions are selected for detection.
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|[[File:CRM.jpg|center|20 px]]
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|Tomer, Guenat, Deterding. Anal. Chem. 60, 2232 (1988).
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|-
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|[[Multiple reaction monitoring]]
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|[[MRM]]
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|Application of [[selected reaction monitoring]] to multiple [[product ion]]s from one or more [[precursor ion]]s.
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:Note: This term should not be confused with [[consecutive reaction monitoring]], which involves the serial application of three or more stages of selected reaction monitoring.
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|[[File:MRM-Single.jpg|center|30 px]]
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|Roepstorff, Fohlman. Biomed. Mass Spectrom. 11, 601 (1984).
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|}
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<includeonly>[[Category:Reactions]][[Category:Reaction monitoring]]
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[[Category:Controversial terms]]</includeonly>

Latest revision as of 13:57, 15 March 2021

Multiple reaction monitoring is not deprecated

Please note that the term multiple reaction monitoring is not deprecated in the IUPAC "Standard definitions of terms relating to mass spectrometry" Pure Appl. Chem., 2013, 85, 1515. There is no small amount of confusion regarding this fact due in part to the seven years that elapsed between the posting of the unreviewed 2006 draft of the document (still linked as "provisional recommendations" on the IUPAC website) and the publication of the peer reviewed document in 2013. Comments from reviewers during the peer review process led to a revision of the definition to what is now indicated on the multiple reaction monitoring page of this wiki. In several publications between 2006 and 2012, the draft definition was cited (e.g. http://dx.doi.org/10.1038/msb.2008.61, http://dx.doi.org/10.1002/pmic.200800577, http://dx.doi.org/10.1039/c0mb00159g, http://dx.doi.org/10.1002/pmic.201200042), inadvertently leading to further confusion. Again, please note that the IUPAC recommendation for multiple reaction monitoring is the one indicated in http://dx.doi.org/10.1351/PAC-REC-06-04-06.

Summary of reaction monitoring definitions

Term Acronym Definition Diagram Reference
Selected ion monitoring SIM Operation of a mass spectrometer in which the abundances of ions of one or more specific m/z values are recorded rather than the entire mass spectrum.      . Gold Book
Selected reaction monitoring SRM Data acquired from one or more specific product ions corresponding to m/z selected precursor ions recorded via two or more stages of mass spectrometry.
Note 1: Selected reaction monitoring in multiple-stage mass spectrometry is known as consecutive reaction monitoring.
Note 2: Selected reaction monitoring applied to multiple product ions from one or more precursor ions is known as multiple reaction monitoring.
SRM.jpg
de Hoffmann. J. Mass Spectrom. 31, 129 (1996).
Consecutive reaction monitoring CRM Multiple-stage mass spectrometry experiment with three or more stages of m/z separation in which products of sequential fragmentation or bimolecular reactions are selected for detection.
CRM.jpg
Tomer, Guenat, Deterding. Anal. Chem. 60, 2232 (1988).
Multiple reaction monitoring MRM Application of selected reaction monitoring to multiple product ions from one or more precursor ions.
Note: This term should not be confused with consecutive reaction monitoring, which involves the serial application of three or more stages of selected reaction monitoring.
MRM-Single.jpg
Roepstorff, Fohlman. Biomed. Mass Spectrom. 11, 601 (1984).