Difference between revisions of "Top-down proteomics"

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A method of protein identification that uses the [[m/z]] selection of intact proteins followed by fragmentation and m/z separation in a second stage of mass spectrometry. Mixtures of proteins must first be separated by liquid chromatography or other separation method prior to mass spectrometry.
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|def=Method of protein identification that uses the ''[[m/z]]'' selection of intact proteins followed by fragmentation and ''m/z'' separation in a second stage of [[mass spectrometry]]. Mixtures of proteins must first be separated by [[wikipedia:high-performance liquid chromatography|liquid chromatography]] or other separation method prior to analysis by mass spectrometry.
#S.K. Sze, Y. Ge, H. Oh, F.W. McLafferty, Proc Natl Acad Sci U S A 99 (2002) 1774.
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#N.L. Kelleher, Anal Chem 76 (2004) 197A.
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|ref=S. K. Sze, Y. Ge, H. Oh, F. W. McLafferty. Proc. Natl. Acad. Sci. USA 99, 1774 (2002). (http://dx.doi.org/10.1073/pnas.251691898 )
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N. L. Kelleher. Anal. Chem. 76, 197A (2004). (http://dx.doi.org/10.1021/ac0415657 )
 
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[[Category:Proteomics]]
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{{ext}}10.1007/s13361-019-02201-x F. Lermyte, Y.O. Tsybin, P.B. O'Connor, J.A. Loo, Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches, J Am Soc Mass Spectrom (2019)

Latest revision as of 17:47, 22 March 2021

IUPAC RECOMMENDATIONS 2013
Top-down proteomics
Method of protein identification that uses the m/z selection of intact proteins followed by fragmentation and m/z separation in a second stage of mass spectrometry. Mixtures of proteins must first be separated by liquid chromatography or other separation method prior to analysis by mass spectrometry.
Related Term(s):
Reference(s):

S. K. Sze, Y. Ge, H. Oh, F. W. McLafferty. Proc. Natl. Acad. Sci. USA 99, 1774 (2002). (http://dx.doi.org/10.1073/pnas.251691898 )

N. L. Kelleher. Anal. Chem. 76, 197A (2004). (http://dx.doi.org/10.1021/ac0415657 )

From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.

Index of Recommended Terms

 




External links

http://dx.doi.org/10.1007/s13361-019-02201-x F. Lermyte, Y.O. Tsybin, P.B. O'Connor, J.A. Loo, Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches, J Am Soc Mass Spectrom (2019)