K.K. Murray, D.H. Russell, “Aerosol Matrix-Assisted Laser-Desorption Ionization Mass-Spectrometry, “ J. Am. Soc. Mass Spectrom. 5 (1994) 1–9. doi:10.1016/1044-0305(94)85077-1.

Abstract: A new method of liquid sample introduction for a time-of-flight mass spectrometer (TOF-MS) has been developed by applying the method of matrix-assisted laser desorption ionization to aerosols. Analyte biomolecules are dissolved in a methanol solvent along with a UVabsorbing matrix and formed into an aerosol with a pneumatic nebulizer. The aerosol particles are dried in a heated skimmer tube before ionization by pulsed 355-nm UV laser radiation. Mass analysis is achieved in a linear TOF-MS. Results for the ionization of bovine insulin (5733.5 Mw) are reported.

Aerosol MALDI apparatus at Texas A&M University
AMALDI side view
Texas A&M Aerosol MALDI instrument side view
TAMU AMALDI Mass Spectrometer 1992
Aerosol MALDI instrument at Texas A&M University, showing the flight tube (right) and ion source (left).
TAMU Roots pump
Roots blower and backing pump at Texas A&M University, 1992
AMALDI Instrument at Texas A&M
Aerosol MALDI Instrument at Texas A&M University, 1992.
Kermit Murray at Texas A&M University in 1993