Laser Ablation with Vacuum Capture for MALDI Mass Spectrometry of Tissue

F. Donnarumma, F. Cao, & K. K. Murray, J. Am. Soc. Mass Spectrom. (2015) DOI: 10.1007/s13361-015-1249-0 We have developed a laser ablation sampling technique for matrix-assisted laser desorption ionization (MALDI) mass spectrometry and tandem mass spectrometry (MS/MS) analyses of in-situ digested tissue proteins. Infrared laser ablation was used to remove biomolecules from tissue sections for […]