Ultra sensitive affinity chromatography on avidin-functionalized PMMA microchip for low abundant post-translational modified protein enrichment

H. Xia, K. Murray, S. Soper, J. Feng, Ultra sensitive affinity chromatography on avidin-functionalized PMMA microchip for low abundant post-translational modified protein enrichment, Biomed. Microdevices, 14 (2012) 67-81; doi: 10.1007/s10544-011-9586-7 Abstract Post-translational modifications (PTM) of proteins play essential roles in cellular physiology and disease. The identification of protein substrates and detection of modification site helps […]

Microfluidics with MALDI analysis for proteomics

J. Lee, S.A. Soper, K.K. Murray, “Microfluidics with MALDI analysis for proteomics–a review,” Anal. Chim. Acta. 649 (2009) 180–190. doi:10.1016/j.aca.2009.07.037. Abstract Various microfluidic devices have been developed for proteomic analyses and many of these have been designed specifically for mass spectrometry detection. In this review, we present an overview of chip fabrication, microfluidic components, and […]