Group News

Wavelength Dependent Atomic Force Microscope Tip-enhanced Laser Ablation

F. Cao, F. Donnarumma, K. K. Murray, Appl. Surf. Sci. DOI:10.1016/j.apsusc.2018.03.239

Abstract

The role of laser wavelength in atomic force microscopy (AFM) tip-enhanced laser ablation was studied using an apertureless tip and a nanosecond pulsed laser. An optical parametric oscillator (OPO) laser wavelength tunable from 410 to 2400 nm was used to irradiate a gold-coated silicon AFM probe held 15 nm above the surface of an anthracene film. The absorption of laser energy by the tip at 532 nm is sufficient to melt the gold coating and increase the diameter of the tip from about 100 nm to approximately 1 µm. The ablation crater volume was measured and found to have a maximum at 500 nm and an approximately linear drop to 800 nm. Craters could not be produced between 800 and 1200 nm and the crater was slightly smaller at 450 nm compared to 500 nm. A crater rim was observed with a volume comparable to that of the crater but lower density. The mechanism of ablation is postulated to be the result of energy absorption by the tip through plasmon resonance of the gold coating followed by melting of the anthracene by ballistic, contact, or radiative heating of the anthracene film.

ASMS 2017

65th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Indianapolis Indiana, June 4 – 8, 2017

Downtown Indianapolis
Downtown Indianapolis
Sunday Tutorial

MALDI – Past and Future, Kermit K. Murray

Monday Poster 644

Combined Proteomic and RNA Expression Analysis of Laser Ablation Extracted Tissue, Chao Dong, Kelin Wang, Fabrizio Donnarumma, Scott W. Herke, Michael E. Pettit, Touradj Solouki,3 and Kermit K. Murray, presented at the 65th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 5, 2017.

Combined Proteomic and RNA Expression Analysis of Laser Ablation Extracted Tissue
Combined Proteomic and RNA Expression Analysis of Laser Ablation Extracted Tissue
Chao Dong ASMS 2017
Chao Dong ASMS 2017
Monday Poster 698

Infrared Laser Ablation Sample Transfer with Conserved Biological Function, Kelin Wang, Matthew D. Baldone, Fabrizio Donnarumma, and Kermit K. Murray, presented at the 65th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 5, 2017.

Infrared Laser Ablation Sample Transfer with Conserved Biological Function
Infrared Laser Ablation Sample Transfer with Conserved Biological Function

Kelin MP698 2017

Tuesday Poster 429

Pulsed Valve Matrix-assisted Ionization, Bijay Banstola and Kermit K. Murray, presented at the 65th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 6, 2017.

Pulsed Valve Matrix-assisted Ionization
Pulsed Valve Matrix-assisted Ionization
Bijay Banstola ASMS 2017
Bijay Banstola ASMS 2017
Tuesday Poster 500

Combined Solid and Liquid Matrix High Vacuum Sublimation and Evaporation Coating for MALDI Imaging, Fan Cao, Fabrizio Donnarumma, Md Amir Hossen, and Kermit K. Murray, presented at the 65th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 6, 2017.

Combined Solid and Liquid Matrix High Vacuum Sublimation and Evaporation Coating for MALDI Imaging
Combined Solid and Liquid Matrix High Vacuum Sublimation and Evaporation Coating for MALDI Imaging
Amir Hossen ASMS 2017
Amir Hossen ASMS 2017
Wednesday Poster 362

Online Atomic Force Microscope Tip-enhanced Laser Ablation Mass Spectrometry, Md Amir Hossen, Bijay Banstola, Fan Cao, and Kermit K. Murray, presented at the 65th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 6, 2017.

Online Atomic Force Microscope Tip-enhanced Laser Ablation Mass Spectrometry
Online Atomic Force Microscope Tip-enhanced Laser Ablation Mass Spectrometry
Remi Lewal, Chao Dong, Kelin Wand, Fan Cao, and Bijay Banstola at ASMS 2017
Remi Lewal, Chao Dong, Kelin Wand, Fan Cao, and Bijay Banstola at ASMS 2017
Thursday Poster 260

Infrared Laser Ablation Microsampling and Data Independent Acquisition Mass Spectrometry for Tissue Proteomics, Kelin Wang, Fabrizio Donnarumma, Carson W .Szot, Michael E. Pettit, Touradj Solouki, and Kermit K. Murray

Infrared Laser Ablation Microsampling and Data Independent Acquisition Mass Spectrometry for Tissue Proteomics
Infrared Laser Ablation Microsampling and Data Independent Acquisition Mass Spectrometry for Tissue Proteomics
Kelin Wang ASMS 2017
Kelin Wang ASMS 2017
Thursday Poster 695

Laser Ablation Capture of Formalin Fixed Paraffin Embedded Tissue for LC-MS/MS Proteomics Analysis, Fabrizio Donnarumma, Michael E. Pettit, Touradj Solouki, and Kermit K. Murray

Laser Ablation Capture of Formalin Fixed Paraffin Embedded Tissue for LC-MS/MS Proteomics Analysis
Laser Ablation Capture of Formalin Fixed Paraffin Embedded Tissue for LC-MS/MS Proteomics Analysis
Fabrizio Donnarumma ASMS 2017
Fabrizio Donnarumma ASMS 2017
Kelin Wang and Fan Cao at ASMS 2017
Kelin Wang and Fan Cao at ASMS 2017
Murray Group Dinner ASMS 2017: Amir Hossen, Chao Dong, Remi Lewal, Kelin Wang, Fan Cao, Fabrizio Donnarumma, Bijay Banstola, Sucharita Dutta, Shelley Jackson, Kermit Murray, Jeonghoon Lee, and Xing Fan
Murray Group Dinner ASMS 2017: Amir Hossen, Chao Dong, Remi Lewal, Kelin Wang, Fan Cao, Fabrizio Donnarumma, Bijay Banstola, Sucharita Dutta, Shelley Jackson, Kermit Murray, Jeonghoon Lee, and Xing Fan
ASMS Livery Indy Car
ASMS Livery Indy Car
Indiana State House at ASMS 2017
Indiana State House at ASMS 2017

Pulsed Valve Matrix-assisted Ionization

DOI: 10.1039/C7AN00489C

PV MAI Schematic
Pulsed valve matrix assisted ionization schematic.

We have developed a new ionization approach for matrix-assisted ionization with high temporal resolution using an electrically actuated pulsed valve. Matrix and analyte samples are deposited on a thin metal foil and placed at the inlet of an ambient ionization mass spectrometer. When the pulsed valve is actuated, a short puff of high pressure gas impinges on the foil and ejects particulate from the sample on the opposite side. Highly charged ions are formed from the particles at the mass spectrometer inlet. Using this source, multiply charged protein ions are produced within a selectable 4 second time window.