We are combining atomic force microscopy (AFM) with near-field tip-enhanced laser ablation for sub-micrometer sampling from cells and tissue. This approach has applications in single cell bioanalysis by mass spectrometry and genomic sequencing.
Ghorai, Seneviratne, Murray, “Tip-Enhanced Laser Ablation Sample Transfer for Biomolecule Mass Spectrometry.” J. Am. Soc. Mass Spectrom. 2015, 26, 63–70.
Murray, Ghorai, Seneviratne, “Tip Enhanced Laser Ablation Sample Transfer for Mass Spectrometry.” MRS Proc. 2015, 1754, mrsf14–1754–pp08–04.