Tip-enhanced laser ablation crater in anthracene
Tip-enhanced laser ablation crater in anthracene a) AFM image, b) depth profile, and c) 3-D view

We are combining atomic force microscopy (AFM) with near-field tip-enhanced laser ablation for sub-micrometer sampling from cells and tissue. This approach has applications in single cell bioanalysis by mass spectrometry and genomic sequencing.

Recent News

Wavelength-Dependent Tip-Enhanced Laser Ablation of Organic Dyes

Patent: Tip Enhanced Laser Assisted Sample Transfer for Biomolecule Mass Spectrometry

Tip-enhanced laser ablation and capture of DNA

ASMS 2018: Droplet Capture Tip-enhanced Laser Ablation Sampling for Mass Spectrometry

2018 Spring ACS: Tip-enhanced Laser Ablation Capture for Single Cell Genomics

Wavelength Dependent Atomic Force Microscope Tip-enhanced Laser Ablation

SciX 2016: Atomic Force Microscope Near-field Laser Ablation Sampling for Proteomics and Genomics

High Resolution Laser Mass Spectrometry Bioimaging

Publications

Conference Presentations