International Mass Spectrometry Conference, Florence, Italy, August 28, 2018 Louisiana State University: Kermit K. Murray, Fabrizio Donnarumma, Kelin Wang, Carson W. Szot, Chao Dong,Baylor University: Touradj Solouki, Michael E. Pettit Introduction Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is a powerful method for determining the location of biomolecules in tissue; however, protein identification and […]
International Mass Spectrometry Conference, Florence, Italy, August 27, 2018 Kermit K. Murray, Remi O. Lawal, and Fabrizio Donnarumma Louisiana State University, Baton Rouge, LA Introduction We are using combined mid-infrared and deep-ultraviolet two-laser ablation coupled with electrospray ionization for ambient mass spectrometry of biomolecules in tissue. The goal is to increase nanoparticle production and improve […]
Wang, K., Donnarumma, F., Baldone, M. D., & Murray, K. K. Infrared laser ablation and capture of enzymes with conserved activity. Anal Chim Acta, 1027, 41–46 (2018). Abstract Infrared (IR) laser ablation at 3 μm wavelength was used to extract enzymes from tissue and quantitatively determine their activity. Experiments were conducted with trypsin, which was ablated, […]
Infrared Laser Ablation Microsampling for Mass Spectrometry Imaging (CHE-1709526) is a $0.35M award to Louisiana State University and Baylor University from the National Science Foundation Division of Chemistry to support the development of new techniques for biological imaging. Thank you NSF for 20+ years of support.
Another laser and the second from OPOTEK this year: an IR Opolette 2940. It is fixed wavelength at 2940 nm for no other reason than that is the Er:YAG laser wavelength. It is possible to manually adjust the internal optics to generate light from 2700 to 3100 nm. This laser has its roots in the […]