ASMS 2023: Are Native Conformations of Proteins Preserved Throughout Laser Ablation?

MP252 AuthorsNeda Feizi Gilandeh1; Blessing Chisom Egbejiogu2; Kyle L. Wilhelm1; Kermit K. Murray2; Touradj Solouki1 Institutes1Baylor University, Waco, TX; 2Louisiana State University, Baton Rouge, LA IntroductionNative electrospray ionization mass spectrometry (n-ESI/MS) combined with ion mobility spectrometry (IMS) provides an opportunity to study indigenous forms of proteins in biological samples. Recently, we reported on combining n-ESI/MS …

IMSC 2018: Infrared Laser Ablation Microsampling Coupled with MALDI Imaging

International Mass Spectrometry Conference, Florence, Italy, August 28, 2018 Louisiana State University: Kermit K. Murray, Fabrizio Donnarumma, Kelin Wang, Carson W. Szot, Chao Dong,Baylor University: Touradj Solouki, Michael E. Pettit Introduction Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is a powerful method for determining the location of biomolecules in tissue; however, protein identification and …

IMSC 2018: Combined Infrared and Ultraviolet Ablation Electrospray Ionization Mass Spectrometry

International Mass Spectrometry Conference, Florence, Italy, August 27, 2018 Kermit K. Murray, Remi O. Lawal, and Fabrizio Donnarumma Louisiana State University, Baton Rouge, LA Introduction We are using combined mid-infrared and deep-ultraviolet two-laser ablation coupled with electrospray ionization for ambient mass spectrometry of biomolecules in tissue. The goal is to increase nanoparticle production and improve …