Small molecule ambient mass spectrometry imaging by infrared laser ablation metastable-induced chemical ionization

Abstract Presented here is a novel ambient ion source termed infrared laser ablation metastable-induced chemical ionization (IR-LAMICI). IR-LAMICI integrates IR laser ablation and direct analysis in real time (DART)-type metastable-induced chemical ionization for open air mass spectrometry (MS) ionization. The ion generation in the IR-LAMICI source is a two step process. First, IR laser pulses […]

Microfluidics with MALDI analysis for proteomics

J. Lee, S.A. Soper, K.K. Murray, “Microfluidics with MALDI analysis for proteomics–a review,” Anal. Chim. Acta. 649 (2009) 180–190. doi:10.1016/j.aca.2009.07.037. Abstract Various microfluidic devices have been developed for proteomic analyses and many of these have been designed specifically for mass spectrometry detection. In this review, we present an overview of chip fabrication, microfluidic components, and […]