High Resolution Laser Mass Spectrometry Bioimaging

K. K. Murray, , C. A. Seneviratne, and S. Ghorai, “High Resolution Laser Mass Spectrometry Bioimaging” Methods 104 (2016) 118–126; doi:10.1016/j.ymeth.2016.03.002 Mass spectrometry imaging (MSI) was introduced more than five decades ago with secondary ion mass spectrometry (SIMS) and a decade later with laser desorption/ionization (LDI) mass spectrometry (MS). Large biomolecule imaging by matrix-assisted laser […]

GUMBOS matrices of variable hydrophobicity for matrix-assisted laser desorption/ionization mass spectrometry

Al Ghafly, Siraj, Das, Regmi, Magut, Galpothdeniya, Murray, Warner, Rapid Commun. Mass Spectrom. 2014, 28, 2307; DOI: 10.1002/rcm.7027. RATIONALE Detection of hydrophobic peptides remains a major obstacle for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). This stems from the fact that most matrices for MALDI are hydrophilic and therefore have low affinities for hydrophobic peptides. Herein, […]