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Laser Ablation Ambient Sampling

Laser Ablation into Electrospray

The efficient material removal of an infrared laser can be used to desorb and ablate material that is then merged with highly charged droplets from an electrospray. With this approach, materials can be analyzed under ambient conditions with the spatial resolution afforded by a focused laser.

Rezenom, Dong, Murray, Infrared Laser-Assisted Desorption Electrospray Ionization Mass Spectrometry. Analyst 2008, 133, 226–232.

Side View of Target for IR Laser + Electrospray
Side View of Target for IR Laser + Electrospray
  • Sampson, J. S.; Murray, K. K.; Muddiman, D. C. Intact and Top-Down Characterization of Biomolecules and Direct Analysis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Coupled to FT-ICR Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2009, 20, 667–673.

    Galhena, A. S.; Harris, G. A.; Nyadong, L.; Murray, K. K.; Fernandez, F. M. Small Molecule Ambient Mass Spectrometry Imaging by Infrared Laser Ablation Metastable-Induced Chemical Ionization. Anal. Chem. 2010, 82, 2178–2181.